In Situ Generation and Intramolecular Schmidt Reaction of Keto Azides in a Microwave-Assisted Flow Format

A two-stage synthesis of lactams in flow is described. Thus, a keto alkyl halide is displaced in a microwave-assisted, continuous flow organic synthesis format (MACOS) to generate a reactive alkyl azide. Without isolation, a flowed solution containing this azide is then combined with TFA to afford a...

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Bibliographic Details
Main Authors: Painter, Thomas O., Thornton, Paul D., Orestano, Mario, Santini, Conrad, Organ, Michael G., Aubé, Jeffrey
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382118/
https://ncbi.nlm.nih.gov/pubmed/21796690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201100768
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