Correction of mouse ornithine transcarbamylase deficiency by gene transfer into the germ line.

The sparse fur with abnormal skin and hair (Spf-ash) mouse is a model for the human X-linked hereditary disorder, ornithine transcarbamylase (OTC) deficiency. In Spf-ash mice, both OTC mRNA and enzyme activity are 5% of control values resulting in hyperammonemia, pronounced orotic aciduria and an ab...

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Dades bibliogràfiques

Publicat a:	Nucleic Acids Res
Autors principals:	Cavard, C, Grimber, G, Dubois, N, Chasse, J F, Bennoun, M, Minet-Thuriaux, M, Kamoun, P, Briand, P
Format:	Artigo
Idioma:	Inglês
Publicat:	Oxford University Press 1988
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC338202/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3162766/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/16.5.2099
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