Correction of mouse ornithine transcarbamylase deficiency by gene transfer into the germ line.
The sparse fur with abnormal skin and hair (Spf-ash) mouse is a model for the human X-linked hereditary disorder, ornithine transcarbamylase (OTC) deficiency. In Spf-ash mice, both OTC mRNA and enzyme activity are 5% of control values resulting in hyperammonemia, pronounced orotic aciduria and an ab...
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| Izdano u: | Nucleic Acids Res |
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| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
1988
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| Online pristup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC338202/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3162766/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/16.5.2099 |
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