Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under Drinking-in-the-Dark procedures

BACKGROUND: Alcohol increases the expression of Group 1 metabotropic glutamate receptors (mGluRs), their associated scaffolding protein Homer2, and stimulates phosphatidylinositol 3-kinase (PI3K) within the nucleus accumbens (NAC). Moreover, functional studies suggest that NAC Group 1 mGluR/Homer2/P...

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Huvudupphovsmän: Cozzoli, Debra K., Courson, Justin, Caruana, Amanda L., Miller, Bailey W., Greentree, Daniel I., Thomspon, Andrew B., Wroten, Melissa G., Zhang, Ping-Wu, Xiao, Bo, Hu, Jia-Hua, Klugmann, Matthias, Metten, Pamela, Worley, Paul F., Crabbe, John C., Szumlinski, Karen K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382009/
https://ncbi.nlm.nih.gov/pubmed/22432643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1530-0277.2012.01776.x
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