Selection Strategy to Generate Aptamer Pairs that Bind to Distinct Sites on Protein Targets

Many analytical techniques benefit greatly from the use of affinity reagent pairs, wherein each reagent recognizes a discrete binding site on a target. For example, antibody pairs have been widely used to dramatically increase the specificity of enzyme linked immunosorbent assays (ELISA). Nucleic ac...

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Bibliographic Details
Main Authors: Gong, Qiang, Wang, Jinpeng, Ahmad, Kareem M., Csordas, Andrew, Zhou, Jiehua, Nie, Jeff, Stewart, Ron, Thomson, James A., Rossi, John J., Soh, H. Tom
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382006/
https://ncbi.nlm.nih.gov/pubmed/22624874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac300873p
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