Mitochondrial Transcription Factor A (TFAM) Serves as a Danger Signal by Augmenting Plasmacytoid Dendritic Cell Responses to DNA()

Plasmacytoid dendritic cells (pDC) are potent antigen-presenting cells known to regulate immune responses to self-antigens, particularly DNA. The mitochondrial fraction of necrotic cells was found to most potently promote human pDC activation, as reflected by Type I interferon release, which was dep...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Julian, Mark W., Shao, Guohong, Bao, Shengying, Knoell, Daren L., Papenfuss, Tracey L., VanGundy, Zachary C., Crouser, Elliott D.
التنسيق: Artigo
اللغة:Inglês
منشور في: 2012
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381894/
https://ncbi.nlm.nih.gov/pubmed/22675199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101375
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