Mitochondrial Transcription Factor A, an Endogenous Danger Signal, Promotes TNFα Release via RAGE- and TLR9-Responsive Plasmacytoid Dendritic Cells

OBJECTIVE: Mitochondrial transcription factor A (TFAM) is normally bound to and remains associated with mitochondrial DNA (mtDNA) when released from damaged cells. We hypothesized that TFAM, bound to mtDNA (or equivalent CpG-enriched DNA), amplifies TNFα release from TLR9-expressing plasmacytoid den...

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Detalhes bibliográficos
Main Authors: Julian, Mark W., Shao, Guohong, VanGundy, Zachary C., Papenfuss, Tracey L., Crouser, Elliott D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741150/
https://ncbi.nlm.nih.gov/pubmed/23951313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072354
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