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Mitochondrial Transcription Factor A (TFAM) Serves as a Danger Signal by Augmenting Plasmacytoid Dendritic Cell Responses to DNA()
Plasmacytoid dendritic cells (pDC) are potent antigen-presenting cells known to regulate immune responses to self-antigens, particularly DNA. The mitochondrial fraction of necrotic cells was found to most potently promote human pDC activation, as reflected by Type I interferon release, which was dep...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3381894/ https://ncbi.nlm.nih.gov/pubmed/22675199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101375 |
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