Directed Therapy for Patients with Myelodysplastic Syndromes (MDS) by Suppression of Cyclin D1 with ON 01910.Na

BACKGROUND: We previously demonstrated upregulation of c-myc, survivin, and cyclin D1 in CD34+ bone marrow mononuclear cells (BMMNCs) of patients with trisomy 8 and monosomy 7 myelodysplastic syndromes (MDS). “Knockdown” of cyclin D1 by RNA interference decreased trisomy 8 cell growth, suggesting th...

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Главные авторы: Olnes, Matthew J., Shenoy, Aarthie, Weinstein, Barbara, Pfannes, Loretta, Loeliger, Kelsey, Tucker, Zachary, Tian, Xin, Kwak, Minjung, Wilhelm, Francois, Yong, Agnes S.M., Maric, Irina, Maniar, Manoj, Scheinberg, Phillip, Groopman, Jerome, Young, Neal S., Sloand, Elaine M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381873/
https://ncbi.nlm.nih.gov/pubmed/22524974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2012.04.002
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