Modification of Interface between Regulatory and Essential Light Chains Hampers Phosphorylation-dependent Activation of Smooth Muscle Myosin

We examined the regulatory importance of interactions between regulatory light chain (RLC), essential light chain (ELC), and adjacent heavy chain (HC) in the regulatory domain of smooth muscle heavy meromyosin. After mutating the HC, RLC, and/or ELC to disrupt their predicted interactions (using sca...

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Detalhes bibliográficos
Main Authors: Ni, Shaowei, Hong, Feng, Haldeman, Brian D., Baker, Josh E., Facemyer, Kevin C., Cremo, Christine R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381165/
https://ncbi.nlm.nih.gov/pubmed/22549781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.343491
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