Okazaki Fragment Processing-independent Role for Human Dna2 Enzyme during DNA Replication

Dna2 is an essential helicase/nuclease that is postulated to cleave long DNA flaps that escape FEN1 activity during Okazaki fragment (OF) maturation in yeast. We previously demonstrated that the human Dna2 orthologue (hDna2) localizes to the nucleus and contributes to genomic stability. Here we inve...

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Detalhes bibliográficos
Main Authors: Duxin, Julien P., Moore, Hayley R., Sidorova, Julia, Karanja, Kenneth, Honaker, Yuchi, Dao, Benjamin, Piwnica-Worms, Helen, Campbell, Judith L., Monnat, Raymond J., Stewart, Sheila A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381158/
https://ncbi.nlm.nih.gov/pubmed/22570476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.359018
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