Polyfunctional Type-1, -2, and -17 CD8(+) T Cell Responses to Apoptotic Self-Antigens Correlate with the Chronic Evolution of Hepatitis C Virus Infection

Caspase-dependent cleavage of antigens associated with apoptotic cells plays a prominent role in the generation of CD8(+) T cell responses in various infectious diseases. We found that the emergence of a large population of autoreactive CD8(+) T effector cells specific for apoptotic T cell-associate...

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Autori principali: Franceschini, Debora, Del Porto, Paola, Piconese, Silvia, Trella, Emanuele, Accapezzato, Daniele, Paroli, Marino, Morrone, Stefania, Piccolella, Enza, Spada, Enea, Mele, Alfonso, Sidney, John, Sette, Alessandro, Barnaba, Vincenzo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380931/
https://ncbi.nlm.nih.gov/pubmed/22737070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002759
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