PD-L1 negatively regulates CD4(+)CD25(+)Foxp3(+) Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV

CD4(+)CD25(+)Foxp3(+) Tregs suppress autoimmune responses. In addition, they limit T cell responses during chronic infection, thereby minimizing T cell–dependent immunopathology. We sought to investigate how Tregs are regulated in the livers of patients chronically infected with HCV, where they cont...

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Главные авторы: Franceschini, Debora, Paroli, Marino, Francavilla, Vittorio, Videtta, Melissa, Morrone, Stefania, Labbadia, Giancarlo, Cerino, Antonella, Mondelli, Mario U., Barnaba, Vincenzo
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2009
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648671/
https://ncbi.nlm.nih.gov/pubmed/19229109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36604
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