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PD-L1 negatively regulates CD4(+)CD25(+)Foxp3(+) Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV
CD4(+)CD25(+)Foxp3(+) Tregs suppress autoimmune responses. In addition, they limit T cell responses during chronic infection, thereby minimizing T cell–dependent immunopathology. We sought to investigate how Tregs are regulated in the livers of patients chronically infected with HCV, where they cont...
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Главные авторы: | , , , , , , , , |
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Формат: | Artigo |
Язык: | Inglês |
Опубликовано: |
American Society for Clinical Investigation
2009
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Предметы: | |
Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2648671/ https://ncbi.nlm.nih.gov/pubmed/19229109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36604 |
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