High Let-7a MicroRNA Levels in KRAS-Mutated Colorectal Carcinomas May Rescue Anti-EGFR Therapy Effects in Patients with Chemotherapy-Refractory Metastatic Disease

Preclinical and experimental data in vivo indicate that Lethal-7 (Let-7) microRNA downregulates KRAS with antitumor effects in the presence of activating KRAS mutations. We quantified the Let-7a isoform in KRAS-mutated colorectal carcinomas from patients who received salvage cetuximab plus irinoteca...

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Detalhes bibliográficos
Main Authors: Ruzzo, Annamaria, Graziano, Francesco, Vincenzi, Bruno, Canestrari, Emanuele, Perrone, Giuseppe, Galluccio, Nadia, Catalano, Vincenzo, Loupakis, Fotios, Rabitti, Carla, Santini, Daniele, Tonini, Giuseppe, Fiorentini, Giammaria, Rossi, David, Falcone, Alfredo, Magnani, Mauro
Formato: Artigo
Idioma:Inglês
Publicado em: AlphaMed Press 2012
Assuntos:
Gastrointestinal Cancer
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380881/
https://ncbi.nlm.nih.gov/pubmed/22584434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2012-0081
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