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Cross-Regulation of Protein Stability by p53 and Nuclear Receptor SHP
We report here a novel interplay between tumor suppressor p53 and nuclear receptor SHP that controls p53 and SHP stability. Overexpression of p53 causes rapid SHP protein degradation, which does not require the presence of Mdm2 and is mediated by the proteosome pathway. Overexpressing SHP alone does...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3380837/ https://ncbi.nlm.nih.gov/pubmed/22737255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039789 |
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