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Mdm2 is a Novel Activator of ApoCIII Promoter Which is Antagonized by p53 and SHP Inhibition
We examined the effect of Mdm2 on regulation of the ApoCIII promoter and its cross-talk with p53 and nuclear receptor SHP. Overexpression of Mdm2 markedly enhanced ApoCIII promoter activity by HNF4α. A direct association of Mdm2 protein with the HNF4α protein was observed by co-immunoprecipitation....
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3259241/ https://ncbi.nlm.nih.gov/pubmed/22197810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.12.027 |
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