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Mdm2 is a Novel Activator of ApoCIII Promoter Which is Antagonized by p53 and SHP Inhibition

We examined the effect of Mdm2 on regulation of the ApoCIII promoter and its cross-talk with p53 and nuclear receptor SHP. Overexpression of Mdm2 markedly enhanced ApoCIII promoter activity by HNF4α. A direct association of Mdm2 protein with the HNF4α protein was observed by co-immunoprecipitation....

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Main Authors: Yang, Zhihong, Zhang, Yuxia, Wang, Li
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259241/
https://ncbi.nlm.nih.gov/pubmed/22197810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.12.027
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