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Evolutionary-inspired probabilistic search for enhancing sampling of local minima in the protein energy surface

BACKGROUND: Despite computational challenges, elucidating conformations that a protein system assumes under physiologic conditions for the purpose of biological activity is a central problem in computational structural biology. While these conformations are associated with low energies in the energy...

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Hlavní autoři: Olson, Brian S, Shehu, Amarda
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380728/
https://ncbi.nlm.nih.gov/pubmed/22759582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-5956-10-S1-S5
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