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Rapid sampling of local minima in protein energy surface and effective reduction through a multi-objective filter

BACKGROUND: Many problems in protein modeling require obtaining a discrete representation of the protein conformational space as an ensemble of conformations. In ab-initio structure prediction, in particular, where the goal is to predict the native structure of a protein chain given its amino-acid s...

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Hlavní autoři: Olson, Brian S, Shehu, Amarda
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908317/
https://ncbi.nlm.nih.gov/pubmed/24564970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-5956-11-S1-S12
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