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Balancing multiple objectives in conformation sampling to control decoy diversity in template-free protein structure prediction

BACKGROUND: Computational approaches for the determination of biologically-active/native three-dimensional structures of proteins with novel sequences have to handle several challenges. The (conformation) space of possible three-dimensional spatial arrangements of the chain of amino acids that const...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:BMC Bioinformatics
Main Authors: Zaman, Ahmed Bin, Shehu, Amarda
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485169/
https://ncbi.nlm.nih.gov/pubmed/31023237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-019-2794-5
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