Structure-Function of the Tumor Suppressor BRCA1

BRCA1, a multi-domain protein, is mutated in a large percentage of hereditary breast and ovarian cancers. BRCA1 is most often mutated in three domains or regions: the N-terminal RING domain, exons 11-13, and the BRCT domain. The BRCA1 RING domain is responsible for the E3 ubiquitin ligase activity o...

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Bibliographische Detailangaben
Hauptverfasser: Clark, Serena L., Rodriguez, Ana M., Snyder, Russell R., Hankins, Gary D.V., Boehning, Darren
Format: Artigo
Sprache:Inglês
Veröffentlicht: Research Network of Computational and Structural Biotechnology (RNCSB) Organization 2012
Schlagworte:
Mini Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380633/
https://ncbi.nlm.nih.gov/pubmed/22737296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5936/csbj.201204005
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