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Structure-Function of the Tumor Suppressor BRCA1
BRCA1, a multi-domain protein, is mutated in a large percentage of hereditary breast and ovarian cancers. BRCA1 is most often mutated in three domains or regions: the N-terminal RING domain, exons 11-13, and the BRCT domain. The BRCA1 RING domain is responsible for the E3 ubiquitin ligase activity o...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Research Network of Computational and Structural Biotechnology (RNCSB) Organization
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3380633/ https://ncbi.nlm.nih.gov/pubmed/22737296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5936/csbj.201204005 |
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