Autoantibody-mediated angiotensin receptor activation contributes to preeclampsia through TNF-alpha signaling

Preeclampsia is a prevalent life-threatening hypertensive disorder of pregnancy whose pathophysiology remains largely undefined. Recently, a circulating maternal autoantibody, the angiotensin II type I receptor agonistic autoantibody (AT(1)-AA), has emerged as a contributor to disease features. Incr...

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Autors principals: Irani, Roxanna A., Zhang, Yujin, Zhou, Cissy Chenyi, Blackwell, Sean C., Hicks, M. John, Ramin, Susan M., Kellems, Rodney E., Xia, Yang
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380607/
https://ncbi.nlm.nih.gov/pubmed/20351341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.110.150540
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