Regulator of G-Protein Signaling–5 Inhibits Bronchial Smooth Muscle Contraction in Severe Asthma

Severe asthma is associated with fixed airway obstruction attributable to inflammation, copious luminal mucus, and increased airway smooth muscle (ASM) mass. Paradoxically, studies demonstrated that the hypertrophic and hyperplastic ASM characteristic of severe asthma has reduced contractile capacit...

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Главные авторы: Yang, Zhao, Balenga, Nariman, Cooper, Philip R., Damera, Gautam, Edwards, Richard, Brightling, Christopher E., Panettieri, Reynold A., Druey, Kirk M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Thoracic Society 2012
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380291/
https://ncbi.nlm.nih.gov/pubmed/22281988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2011-0110OC
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