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Long-Term Exposure to Hexavalent Chromium Inhibits Expression of Tumor Suppressor Genes in cultured Cells and in Mice
We have used mouse hepatoma cells in culture to study acute, short-term high-dose effects of hexavalent chromium on gene regulation directed by the polycyclic aromatic hydrocarbon benzo[a]pyrene (BaP). We find that the mixture engages three major signaling pathways: (i) activation of detoxification...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3380135/ https://ncbi.nlm.nih.gov/pubmed/22613061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtemb.2012.04.009 |
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