Rapid Assembly of a Library of Lipophilic Iminosugars via the Thiol–Ene Reaction Yields Promising Pharmacological Chaperones for the Treatment of Gaucher Disease

[Image: see text] A highly divergent route to lipophilic iminosugars that utilizes the thiol–ene reaction was developed to enable the rapid synthesis of a collection of 16 dideoxyiminoxylitols bearing various different lipophilic substituents. Enzyme kinetic analyses revealed that a number of these...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Goddard-Borger, Ethan D., Tropak, Michael B., Yonekawa, Sayuri, Tysoe, Christina, Mahuran, Don J., Withers, Stephen G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380069/
https://ncbi.nlm.nih.gov/pubmed/22360565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201633y
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados