Probing the Inhibitor versus Chaperone Properties of sp(2)-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease

A series of sp(2)-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern (d-gluco or l-ido), the architecture of the glycone skeleton, and the nature of the nonglycone substituent has been synthesized and assayed for their inhibition properties towar...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Mena-Barragán, Teresa, García-Moreno, M. Isabel, Sevšek, Alen, Okazaki, Tetsuya, Nanba, Eiji, Higaki, Katsumi, Martin, Nathaniel I., Pieters, Roland J., Fernández, José M. García, Mellet, Carmen Ortiz
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6017062/
https://ncbi.nlm.nih.gov/pubmed/29673163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23040927
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