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Celastrol increases glucocerebrosidase activity in Gaucher disease by modulating molecular chaperones
Gaucher disease is caused by mutations in the glucosidase, beta, acid gene that encodes glucocerebrosidase (GCase). Glucosidase, beta, acid mutations often cause protein misfolding and quantitative loss of GCase. In the present study, we found that celastrol, an herb derivative with known anticancer...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3890874/ https://ncbi.nlm.nih.gov/pubmed/24351928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321341111 |
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