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Histone deacetylase inhibitors increase glucocerebrosidase activity in Gaucher disease by modulation of molecular chaperones

Gaucher disease is caused by mutations of the GBA gene that encodes the lysosomal enzyme glucocerebrosidase (GCase). GBA mutations often result in protein misfolding and premature degradation, but usually exert less effect on catalytic activity. In this study, we identified the molecular mechanism b...

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Détails bibliographiques
Auteurs principaux: Yang, Chunzhang, Rahimpour, Shervin, Lu, Jie, Pacak, Karel, Ikejiri, Barbara, Brady, Roscoe O., Zhuang, Zhengping
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549125/
https://ncbi.nlm.nih.gov/pubmed/23277556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1221046110
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