µ-Calpain Conversion of Antiapoptotic Bfl-1 (BCL2A1) into a Prodeath Factor Reveals Two Distinct alpha-Helices Inducing Mitochondria-Mediated Apoptosis

Anti-apoptotic Bfl-1 and pro-apoptotic Bax, two members of the Bcl-2 family sharing a similar structural fold, are classically viewed as antagonist regulators of apoptosis. However, both proteins were reported to be death inducers following cleavage by the cysteine protease µ-calpain. Here we demons...

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Autors principals: Valero, Juan García, Cornut-Thibaut, Aurélie, Jugé, Romain, Debaud, Anne-Laure, Giménez, Diana, Gillet, Germain, Bonnefoy-Bérard, Nathalie, Salgado, Jesús, Salles, Gilles, Aouacheria, Abdel, Kucharczak, Jérôme
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379997/
https://ncbi.nlm.nih.gov/pubmed/22745672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038620
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