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Genome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes

Signal Transducers and Activators of Transcription (STAT) 5A/B regulate cytokine-inducible genes upon binding to GAS motifs. It is not known what percentage of genes with GAS motifs bind to and are regulated by STAT5. Moreover, it is not clear whether genome-wide STAT5 binding is modulated by its co...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhu, Bing-Mei, Kang, Keunsoo, Yu, Ji Hoon, Chen, Weiping, Smith, Harold E., Lee, Daeyoup, Sun, Hong-Wei, Wei, Lai, Hennighausen, Lothar
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378893/
https://ncbi.nlm.nih.gov/pubmed/22319210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks056
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