Loss of EZH2 results in precocious mammary gland development and activation of STAT5-dependent genes

Establishment and differentiation of mammary alveoli during pregnancy are controlled by prolactin through the transcription factors STAT5A and STAT5B (STAT5), which also regulate temporal activation of mammary signature genes. This study addressed the question whether the methyltransferase and trans...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Yoo, Kyung Hyun, Oh, Sumin, Kang, Keunsoo, Hensel, Tim, Robinson, Gertraud W., Hennighausen, Lothar
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
Schlagworte:
Gene regulation, Chromatin and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4605299/
https://ncbi.nlm.nih.gov/pubmed/26250110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv776
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