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RNA folding with soft constraints: reconciliation of probing data and thermodynamic secondary structure prediction
Thermodynamic folding algorithms and structure probing experiments are commonly used to determine the secondary structure of RNAs. Here we propose a formal framework to reconcile information from both prediction algorithms and probing experiments. The thermodynamic energy parameters are adjusted usi...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3378861/ https://ncbi.nlm.nih.gov/pubmed/22287623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks009 |
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