Long-Term Pioglitazone Treatment Improves Learning and Attenuates Pathological Markers in a Mouse Model of Alzheimer’s Disease

Thiazolidinediones (TZDs) are agonists at peroxisome proliferator-activated gamma-type (PPAR-γ) receptors and are used clinically for the treatment of type 2 diabetes where they have been shown to reestablish insulin sensitivity, improve lipid profiles, and reduce inflammation. Recent work also sugg...

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Main Authors: Searcy, James L., Phelps, Jeremiah T., Pancani, Tristano, Kadish, Inga, Popovic, Jelena, Anderson, Katie L., Beckett, Tina L., Murphy, Michael P., Chen, Kuey-Chu, Blalock, Eric M., Landfield, Philip W., Porter, Nada M., Thibault, Olivier
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378773/
https://ncbi.nlm.nih.gov/pubmed/22495349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2012-111661
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