Effects of Long-Term Pioglitazone Treatment on Peripheral and Central Markers of Aging

BACKGROUND: Thiazolidinediones (TZDs) activate peroxisome proliferator-activated receptor gamma (PPARγ) and are used clinically to help restore peripheral insulin sensitivity in Type 2 diabetes (T2DM). Interestingly, long-term treatment of mouse models of Alzheimer's disease (AD) with TZDs also...

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Detalhes bibliográficos
Main Authors: Blalock, Eric M., Phelps, Jeremiah T., Pancani, Tristano, Searcy, James L., Anderson, Katie L., Gant, John C., Popovic, Jelena, Avdiushko, Margarita G., Cohen, Don A., Chen, Kuey-Chu, Porter, Nada M., Thibault, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861595/
https://ncbi.nlm.nih.gov/pubmed/20454453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010405
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