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Anti-HIV-1 Activity of the Neurokinin-1 Receptor Antagonist Aprepitant and Synergistic Interactions with other Antiretrovirals
OBJECTIVES: Neurokinin-1 receptor (NK1R) antagonists interfere with binding of neuropeptide substance P (SP) to NK1R and exhibit novel anti-HIV-1 activities. Since NK1R antagonists effectively penetrate the blood-brain barrier to reduce the inflammatory response within the brain, we wished to evalua...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3378647/ https://ncbi.nlm.nih.gov/pubmed/20975512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e3283405c33 |
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