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Neurokinin-1 Receptor Antagonist (Aprepitant) Suppresses HIV-1 Infection of Microglia/Macrophages

Neurokinin-1 receptor (NK-1R) antagonists suppress HIV-1 infection of macrophages in vitro. We have further investigated the anti-HIV-1 activity of aprepitant, a Food and Drug Administration-approved NK-1R antagonist, and its cytotoxic effect in the macrophage/microglia system. Aprepitant inhibited...

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Detalhes bibliográficos
Main Authors: Wang, Xu, Douglas, Steven D., Song, Li, Wang, Yan-Jian, Ho, Wen-Zhe
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675876/
https://ncbi.nlm.nih.gov/pubmed/18654860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11481-008-9117-3
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