A Randomized, Placebo Controlled, Double Masked Phase IB Study Evaluating the Safety and Antiviral Activity of Aprepitant, a Neurokinin-1 Receptor Antagonist in HIV-1 Infected Adults

BACKGROUND: Neurokinin-1 receptor (NK1R) antagonists have anti-HIV activity in monocyte-derived macrophages, decrease CCR5 expression and improve natural killer cell function ex vivo. Aprepitant is a NK1R antagonist approved by FDA as an antiemetic. METHODS: We conducted a phase IB randomized, place...

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Autors principals: Tebas, Pablo, Tuluc, Florin, Barrett, Jeffrey S., Wagner, Wayne, Kim, Deborah, Zhao, Huaquing, Gonin, René, Korelitz, James, Douglas, Steven D.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169584/
https://ncbi.nlm.nih.gov/pubmed/21931661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024180
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