Estrogen Modulates NFκB Signaling by Enhancing IκBα Levels and Blocking p65 Binding at the Promoters of Inflammatory Genes via Estrogen Receptor-β

BACKGROUND: NFκB signaling is critical for expression of genes involved in the vascular injury response. We have shown that estrogen (17β-estradiol, E2) inhibits expression of these genes in an estrogen receptor (ER)-dependent manner in injured rat carotid arteries and in tumor necrosis factor (TNF)...

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Detalhes bibliográficos
Main Authors: Xing, Dongqi, Oparil, Suzanne, Yu, Hao, Gong, Kaizheng, Feng, Wenguang, Black, Jonathan, Chen, Yiu-Fai, Nozell, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378567/
https://ncbi.nlm.nih.gov/pubmed/22723832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036890
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