Control of pH responsive peptide self-association during endocytosis is required for effective gene transfer

Cationic amphipathic histidine rich peptides demonstrate differential nucleic acid binding capabilities at neutral and acidic pH and adopt conformations at acidic pH that enable interaction with endosomal membranes, their subsequent disordering and facilitate entry of cargo to the cell cytosol. To b...

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Detalhes bibliográficos
Main Authors: Iacobucci, Valentina, Di Giuseppe, Francesca, Bui, Tam T., Vermeer, Louic S., Patel, Jayneil, Scherman, Daniel, Kichler, Antoine, Drake, Alex F., Mason, A. James
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378503/
https://ncbi.nlm.nih.gov/pubmed/22226847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2011.12.018
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