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Pregnancy reduces RhoA/Rho kinase and protein kinase C signaling pathways downstream of thromboxane receptor activation in the rat uterine artery

During pregnancy, reduced vascular responses to constrictors contribute to decreased uterine and total vascular resistance. Thromboxane A(2) (TxA(2)) is a potent vasoconstrictor that exerts its actions via diverse signaling pathways, and its biosynthesis increases in preeclampsia. In this study, we...

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Detalhes bibliográficos
Main Authors: Goulopoulou, Styliani, Hannan, Johanna L., Matsumoto, Takayuki, Webb, R. Clinton
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378266/
https://ncbi.nlm.nih.gov/pubmed/22542618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00900.2011
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