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Knockout of Mkp-1 exacerbates colitis in Il-10-deficient mice
Il-10-deficient mice develop colitis associated with exaggerated Th1/Th17 responses and are a valuable model of inflammatory bowel disease. Mkp-1 is a major negative regulator of MAPKs, and its expression is enhanced by IL-10. To understand the role of Mkp-1 in the regulation of intestinal mucosal i...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Physiological Society
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3378166/ https://ncbi.nlm.nih.gov/pubmed/22461024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00018.2012 |
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