Knockout of Mkp-1 exacerbates colitis in Il-10-deficient mice

Il-10-deficient mice develop colitis associated with exaggerated Th1/Th17 responses and are a valuable model of inflammatory bowel disease. Mkp-1 is a major negative regulator of MAPKs, and its expression is enhanced by IL-10. To understand the role of Mkp-1 in the regulation of intestinal mucosal i...

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Autores principales: Matta, Ranyia, Barnard, John A., Wancket, Lyn M., Yan, Jing, Xue, Jianjing, Grieves, Jessica, Frazier, W. Joshua, Nelin, Leif, Cato, Andrew C. B., Liu, Yusen
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2012
Materias:
Inflammation/Immunity/Mediators
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378166/
https://ncbi.nlm.nih.gov/pubmed/22461024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00018.2012
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