Increased Inflammation, Impaired Bacterial Clearance, and Metabolic Disruption after Gram-Negative Sepsis in Mkp-1-Deficient Mice

MAPKs are crucial for TNF-α and IL-6 production by innate immune cells in response to TLR ligands. MAPK phosphatase 1 (Mkp-1) deactivates p38 and JNK, abrogating the inflammatory response. We have previously demonstrated that Mkp-1(−/−) mice exhibit exacerbated inflammatory cytokine production and i...

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Main Authors: Frazier, W. Joshua, Wang, Xianxi, Wancket, Lyn M., Li, Xiang-An, Meng, Xiaomei, Nelin, Leif D., Cato, Andrew C. B., Liu, Yusen
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882055/
https://ncbi.nlm.nih.gov/pubmed/19890037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0804343
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