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Deletion of prolyl carboxypeptidase attenuates the metabolic effects of diet-induced obesity
α-Melanocyte-stimulating hormone (α-MSH) is a critical regulator of energy metabolism. Prolyl carboxypeptidase (PRCP) is an enzyme responsible for its degradation and inactivation. PRCP-null mice (PRCP(gt/gt)) showed elevated levels of brain α-MSH, reduced food intake, and a leaner phenotype compare...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Physiological Society
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3378159/ https://ncbi.nlm.nih.gov/pubmed/22454290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00544.2011 |
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