Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

Mutations of the mitochondrial PTEN (phosphatase and tensin homologue)-induced kinase1 (PINK1) are important causes of recessive Parkinson disease (PD). Studies on loss of function and overexpression implicate PINK1 in apoptosis, abnormal mitochondrial morphology, impaired dopamine release and motor...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Morais, Vanessa A, Verstreken, Patrik, Roethig, Anne, Smet, Joél, Snellinx, An, Vanbrabant, Mieke, Haddad, Dominik, Frezza, Christian, Mandemakers, Wim, Vogt-Weisenhorn, Daniela, Van Coster, Rudy, Wurst, Wolfgang, Scorrano, Luca, De Strooper, Bart
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2009
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378121/
https://ncbi.nlm.nih.gov/pubmed/20049710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.200900006
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados