Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

Mutations of the mitochondrial PTEN (phosphatase and tensin homologue)-induced kinase1 (PINK1) are important causes of recessive Parkinson disease (PD). Studies on loss of function and overexpression implicate PINK1 in apoptosis, abnormal mitochondrial morphology, impaired dopamine release and motor...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Morais, Vanessa A, Verstreken, Patrik, Roethig, Anne, Smet, Joél, Snellinx, An, Vanbrabant, Mieke, Haddad, Dominik, Frezza, Christian, Mandemakers, Wim, Vogt-Weisenhorn, Daniela, Van Coster, Rudy, Wurst, Wolfgang, Scorrano, Luca, De Strooper, Bart
Format: Artigo
Sprog:Inglês
Udgivet: WILEY-VCH Verlag 2009
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378121/
https://ncbi.nlm.nih.gov/pubmed/20049710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.200900006
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker