Oxygen-independent degradation of HIF-α via bioengineered VHL tumour suppressor complex

Tumour hypoxia promotes the accumulation of the otherwise oxygen-labile hypoxia-inducible factor (HIF)-α subunit whose expression is associated with cancer progression, poor prognosis and resistance to conventional radiation and chemotherapy. The oxygen-dependent degradation of HIF-α is carried out...

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Autores principales: Sufan, Roxana I, Moriyama, Eduardo H, Mariampillai, Adrian, Roche, Olga, Evans, Andrew J, Alajez, Nehad M, Vitkin, I Alex, Yang, Victor X D, Liu, Fei-Fei, Wilson, Brian C, Ohh, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: WILEY-VCH Verlag 2009
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378113/
https://ncbi.nlm.nih.gov/pubmed/20049704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.200900004
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