The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease

A novel class of antibiotic acyldepsipeptides (designated ADEPs) exerts its unique antibacterial activity by targeting the peptidase caseinolytic protease P (ClpP). ClpP forms proteolytic complexes with heat shock proteins (Hsp100) that select and process substrate proteins for ClpP-mediated degrada...

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Autors principals: Kirstein, Janine, Hoffmann, Anja, Lilie, Hauke, Schmidt, Ronny, Rübsamen-Waigmann, Helga, Brötz-Oesterhelt, Heike, Mogk, Axel, Turgay, Kürşad
Format: Artigo
Idioma:Inglês
Publicat: WILEY-VCH Verlag 2009
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378108/
https://ncbi.nlm.nih.gov/pubmed/20049702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.200900002
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