Compound 49b Prevents Diabetes-Induced Apoptosis through Increased IGFBP-3 Levels

PURPOSE. To determine whether Compound 49b, a novel PKA-activating drug, can prevent diabetic-like changes in the rat retina through increased insulin-like growth factor binding protein-3 (IGFBP-3) levels. METHODS. For the cell culture studies, we used both human retinal endothelial cells (REC) and...

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Main Authors: Zhang, Qiuhua, Guy, Kimberly, Pagadala, Jayaprakash, Jiang, Youde, Walker, Robert J, Liu, Luhong, Soderland, Carl, Kern, Timothy S, Ferry, Robert, He, Hui, Yates, C. Ryan, Miller, Duane D, Steinle, Jena J
Format: Artigo
Language:Inglês
Published: The Association for Research in Vision and Ophthalmology 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378083/
https://ncbi.nlm.nih.gov/pubmed/22467575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.11-8779
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