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IL-27 Inhibits OSM-mediated TNF-α and iNOS Gene Expression in Microglia

Elevated levels of Oncostatin M (OSM), an interleukin-6 family cytokine, have been observed in Multiple Sclerosis (MS), HIV-associated Neurocognitive Disorder (HAND) and glioblastoma (GBM); however, its effects within the CNS are not well understood. OSM regulates gene expression primarily by activa...

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Detalhes bibliográficos
Main Authors: Baker, Brandi J., Park, Keun W., Qin, Hongwei, Ma, Xiangyu, Benveniste, Etty N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378052/
https://ncbi.nlm.nih.gov/pubmed/20468050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.20989
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