Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch critical for myocardial adaptation to ischemia

Studies of metabolic adaptation during environmental stress have broad applications to human disease. Adenosine signaling has been implicated in cardiac adaptation to limited oxygen availability. Serendipitously, a wide search for adenosine receptor A2b (Adora2b)-elicited cardio-adaptive responses i...

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Detalhes bibliográficos
Main Authors: Eckle, Tobias, Hartmann, Katherine, Bonney, Stephanie, Reithel, Susan, Mittelbronn, Michel, Walker, Lori A., Lowes, Brian D., Han, Jun, Borchers, Christoph H., Buttrick, Peter M., Kominsky, Douglas J., Colgan, Sean P., Eltzschig, Holger K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378044/
https://ncbi.nlm.nih.gov/pubmed/22504483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2728
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