Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch critical for myocardial adaptation to ischemia

Studies of metabolic adaptation during environmental stress have broad applications to human disease. Adenosine signaling has been implicated in cardiac adaptation to limited oxygen availability. Serendipitously, a wide search for adenosine receptor A2b (Adora2b)-elicited cardio-adaptive responses i...

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Hauptverfasser: Eckle, Tobias, Hartmann, Katherine, Bonney, Stephanie, Reithel, Susan, Mittelbronn, Michel, Walker, Lori A., Lowes, Brian D., Han, Jun, Borchers, Christoph H., Buttrick, Peter M., Kominsky, Douglas J., Colgan, Sean P., Eltzschig, Holger K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378044/
https://ncbi.nlm.nih.gov/pubmed/22504483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2728
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